A sodium methanol methanol solution is prepared by mixing sodium metal and methanol. Next, add dimethylformamide and Cu2I2, then add 1,3,5-tribromobenzene, heat to 80-90 degrees Celsius, stir and reflux for 2-3 hours. After filtration, methanol and dimethylformamide were evaporated under reduced pressure, and then distilled with water vapor. The crystals were cooled, filtered, and dried to obtain 1,3,5-trimethoxybenzene. This method has low production cost, high purity of the obtained product, and a yield of over 80%.
Mix methanol and catalyst under argon protection, control the pressure to 7 atmospheres, and maintain the temperature at 135 ℃ for 30 minutes. Add a solution composed of 1,3,5-tribromobenzene and toluene dropwise, followed by triethylamine dropwise. Control the temperature to 165 ℃ and the pressure to 11 atmospheres, and react for 11 hours. This method uses specific catalyst preparation methods, including a mixture of sodium oxide and barium oxide, as well as specific reaction conditions.
2,4,6-tribromoaniline is prepared to synthesize 1,3,5-Tribromobenzene, which is then subjected to methoxylation reaction with sodium methoxide. This method uses 1,3,5-tribromobenzene as the raw material and synthesizes 1,3,5-trimethoxybenzene in a simple and high-yield manner through methoxylation reaction. The use of cuprous halide as a reaction catalyst without adding reaction solvents has improved product purity and yield, and reduced production costs.
These methods each have their own characteristics, including considerations of production cost, product purity, yield, and other aspects. The choice of appropriate method depends on specific production needs and cost-benefit analysis.
